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Nutr Metab Cardiovasc Dis 2008;18:74-83

By inhibiting DPP-4, one can enhance the half-life of GLP-1 and GIP already existing in the body

Most GLP-1 medications start at a low dose to reduce gastrointestinal side effects

Sometimes the medication itself is to blame

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

Meanwhile, a report by the BBC has asked whether widespread use of GLP-1 drugs could be leading to a spike in gallbladder removal surgeries called cholecystectomies which are currently being carried out at the highest level in a decade in the UK