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Abbreviations GLP-1: Glucagon-like peptide 1 PCOS: Polycystic ovary syndrome RNA-seq: Ribonucleic acid sequencing functional MRI: Functional magnetic resonance imaging GLP-1 RAs: Glucagon-like peptide 1 receptor agonists NTS: Nucleus solitary tract DHEAS: Dehydroepiandrosterone sulphate PCOM: Polycystic ovarian BMI: Body mass index AE: Adverse event SAR: Serious adverse reaction SRL: Subject randomization list UN: Unique number DXA: Dual-energy X-ray absorptiometry VAT: Visceral adipose tissue TFEQ-R18: Three-Factor Eating Questionnaire-R18 RIA: Radioimmunoassay CV: Coefficient variation NGT: Normal glucose tolerance 2h-OGTT: 2-h oral glucose tolerance test IFG: Impaired fasting glucose CR: Cognitive restraint UE: Uncontrolled eating EE: Emotional eating MSG: Monosodium glutamate ITT: Intention-to-treat PP: Per-protocol DE: Differential expression FDR: False discovery rate CNS: Central nervous system References de Graaf C

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Fill remaining calories with quality fat sources for hormone production and satiety