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Reconstitution, Storage, and Handling Protocols IGF-1 LR3 is supplied as lyophilized powder and must be reconstituted with bacteriostatic water before use

95 CI 13.4 to 11.5

Ozempic reduced the annual rate of change in eGFR 1 For adults with T2D and CKD for a confirmatory secondary endpoint: observed mean change in eGFR over time (the annual rate of change in eGFR) vs placebo when both were added to standard of care 1,2 Observed mean plot: eGFR (mL/min/1.73 m 2 ) by week in FLOW trial 1,2,ff ff Observed data from the in-trial period until Week 104

Packaging: Sealed sterile borosilicate glass vials, multiple sizes available

Image is for illustrative purposes only

However, this study did not use Grading of Recommendations Assessment, Development and Evaluation (GRADE) to assess the level of evidence, creating some resistance to clinical dissemination