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TMX-intoxicated rats had significantly higher expression levels of cleaved caspase-3 ( F (3, 16) = 105.83

waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Liu et al., 2006) (Figure 3)

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The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma

6d), we moved forward to evaluate the combination treatment in the more complex orthotopic GEMM models of CRC

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