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This perspective takes a look back at the contributions of this and related work in the context of plant biology research at the time, and considers the importance of the pathway within our current understanding of reactive oxygen species biology and redox homeostasis and signalling
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Glutathione (GSH) is a crucial antioxidant in the brain
Acknowledgements We thank Keiji Tanaka for the discussions
We conducted searches using the following search terms: cisplatin, cancer, cisplatin nephrotoxicity, acute kidney injury, cisplatin-induced AKI, autophagy, AMPK-mTOR-mediated autophagy, necroptosis, RIPK1/RIPK3/MLKL-mediated necroptosis, necroinflammation, nephroprotective, autophagy activators, and necroptosis inhibitors
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