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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )
contemporaneous legal and pharmacy analyses put the figure at roughly twelve to fourteen
doi: 10.1016/j.yebeh.2014.09.081
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Distinguishing Purging From Adverse Reactions This distinction determines your course of action
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