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While validation in an independent cohort is required, the PREDICT study has potentially identified genetic markers that may have clinical utility in predicting early IGF-I generation and that could contribute to individualization of r-hGH dosing

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The mechanistic basis for combining AHK-Cu and GHK-Cu rests on their partially non-overlapping biological activities

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Notably, STEAP1 expression is sustained in even PSMA-negative prostate tumors and metastatic sites, providing an opportune target for patients with mCRPC

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