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GLP-1-only therapies have an established track record, but adding GIP receptor activation amplifies those effects: appetite suppression is stronger, insulin sensitivity improves through two mechanisms at once, and blood sugar regulation benefits from both pathways working together

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Ensuring adequate protein intake, maintaining hydration, and preserving sleep quality help manage fatigue

It primarily affects skin pigment

Symptoms such as fatigue, headaches, or "sensitivity" to chemicals are nonspecific and can reflect numerous biological and environmental influences beyond GSTM1

Real-world evidence suggests that these patients can benefit from semaglutide therapy when indicated for diabetes or weight management