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[31] developed a hydroquinone-induced C57BL/6 mouse model, in which topical application of apigenin increased melanin content in hair follicles by enhancing TYR expression, and promoting melanin synthesis

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Rhynchophylline A natural alkaloid, rhynchophylline is the main bioactive ingredient of Uncaria rhynchophylla (Miq.) Miq., and attenuates lipopolysaccharide-induced pro-inflammatory responses [73, 205]