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Talking to a healthcare provider before taking L-arginine supplements is essential to ensure safety and proper dosage

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A randomized controlled trial in older obese adults demonstrated that participants in the diet-only group exhibited a 6.2% reduction in thigh muscle volume, whereas those in the exercise group saw a 2.7% increase

Diabetes-induced microvascular alterations, including the thickening of the capillary basement membrane and endothelial hyperplasia, diminish blood flow to nerves, leading to ischemia and subsequent nerve fiber damage

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While acute supplementation of 4.5 grams was previously shown to provide significant enhancement of anaerobic work capacity, the present study suggests that chronic supplementation of GPLC at 3.0 or 4.5 grams daily does not improve anaerobic performance of repeated high speed high intensity bouts and may actually produce detrimental effects with high velocity, high intensity exercise