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Unreported symptoms While the population the researchers studied is admittedly not representative - Reddit users are younger, more likely to be male and disproportionately based in the United States - the symptoms described in their collective accounts largely match the known side effects of semaglutide and tirzepatide: about 44% of users in the study described at least one side effect, most commonly some form of gastrointestinal distress
They improve insulin sensitivity, lower HbA1c, reduce blood pressure, and improve lipid profiles
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Beyond receptor pharmacology, tirzepatide has been characterised in multiple tissue systems
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