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The native GLP-1 hormone is released from intestinal L-cells after food intake and helps regulate glucose-dependent insulin secretion, glucagon suppression, gastric emptying, and satiety signaling
So not only is there limited evidence these supplements can aid in weight management, many have potential side-effects some of which can be quite severe
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The addition of glucagon receptor activation increases energy expenditure and fat oxidation beyond what GLP-1 alone can achieve
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