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Although we did not find any significant difference between soluble Flt-1, also known as vascular endothelial growth factor receptor 1, levels in the plasma of R and LC patients, LC group exhibits a significant plasma elevation compared to the HC cohort ( Figure 6I )

Stoian et al

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These findings suggest that PD potentiates MTX-induced senescence through modulation of cell cycle regulators and inhibition of the TGF-/p-Smad2/4 pathway, highlighting its potential as a senolytic adjuvant in liver cancer therapy

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