The peptide does not simply mask pain like cortisone or anti-inflammatory medications
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As you can see from the side-by-side Figure below, the new trial (at left) replicates the previous one for symptomatic benefit and reduced physical limitations (Y-axis, corresponding to the Kansas City score) with the primary endpoint findings remarkably similar
It slows gastric emptying, stimulates insulin release, suppresses appetite signals in the hypothalamus, and reduces the rewarding quality of food by acting on dopaminergic pathways
While GLP-1 agonists produce dramatic results for many patients, a meaningful subset achieves suboptimal weight loss or experiences diminishing efficacy over time