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Resveratrol induces glutathione synthesis by activation of nuclear erythroid-related factor 2 and by decreasing oxidative stress

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Nrf2 was found to participate in transcriptional activation of antioxidant enzymes that act as a cell defensive system to detoxify NAPQI (Goldring et al., 2004)

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Despite these promising findings, further research is necessary to establish their long-term efficacy, optimal dosing strategies, and potential synergistic interactions of GLP-1RAs with existing pain management therapies

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