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The trick is to overcome the lack of thirst signal caused by the medication: Use non-water fluids: If drinking plain water feels difficult, try different options

These factors are essential for achieving long-term weight management and metabolic improvement while making the journey smooth for the patient

It takes time for new skin cells to reach the surface

For other time-sensitive oral medications, monitoring for efficacy may be warranted, especially during tirzepatide initiation and dose escalation

Your Weight Loss Program with Semaglutide will be supervised by your Forum Health provider and health coaches who are always available to answer questions and ensure you reach your weight-loss goals

doi: 10.3389/fragi.2025.1691007 Received 22 August 2025 Revised 30 October 2025 Accepted 06 November 2025 Published 27 November 2025 Volume 6 - 2025 Edited by Kieran Reid, Harvard Medical School, United States Reviewed by Shannon Hernon, Harvard Medical School, United States Nicole Bajdek, Harvard Medical School, United States Updates Copyright 2025 Dinkla, Beavers, Robbins, Akpalu, Wherry, Miller, Beavers, Espinoza, Trejo, Stepanenko and Cortes