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The exocrine pancreas has GLP-1 receptors, mainly on the acinar cells
Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition
In an ovariectomized mouse model, an antibody (for humans and mice) to FSH (was initially found to inhibit bone resorption and stimulate bone synthesis (61)
Zuo, J., Zhang, Z., Luo, M., Zhou, L., Nice, E
Other important safety considerations include injection site reactions, increased heart rate (a class effect, though potentially more pronounced with liraglutide), and risk of pancreatitis (which requires immediate discontinuation if suspected)
However, medications that are FDA approved for weight loss may be covered if theyre prescribed for a different FDA approved indication
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