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In vitro , overexpression of PACS-2 in HK-2 cells restores reticulophagy via TFEB/family with sequence similarity 134 member B pathway ( Autophagy disruption is caused by multiple-level abnormalities in upstream signaling pathways (117, 152)

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Oral ingestion of HC increases the levels of collagen-derived peptides in the blood torrent and improves the skin properties such as elasticity, skin moisture, and transepidermal water loss

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