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Persistent or rapidly progressing thinning may require evaluation for an underlying medical, nutritional, hormonal, or inflammatory cause
The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks
(2021) demonstrated that escalating doses were well-tolerated in humans with no dose-limiting toxicities
B12 is water soluble, which means B12 doesnt build up in your system once youre at the appropriate amount for your body you will just eliminate any extra, so theres very little risk of an overdose
R.PastanI
But they are structurally unrelated molecules with different origins, different best-studied uses, and importantly different regulatory footprints
