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GLP-1 is an incretin hormone produced in the gut that enhances insulin secretion in response to food intake while suppressing glucagon, slowing gastric emptying, and reducing appetite ( [1] ) ( [2] )
Stephens FB y otros
Importantly, this region contributes much less to receptor binding than to binding-protein binding, which is what makes the modification useful: it separates the two interactions rather than weakening both
Nature 205, 698699
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