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Importantly, converging clinical and preclinical data support a bidirectional interplay whereby circadian disruption and sleep disorders not only emerge early in the disease course, but also aggravate neurodegenerative processes and deeply affect the quality of life of patients and caregivers, underscoring the potential of circadian-based interventions as disease-modifying strategies [13]
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Adiponectin, a hormone associated with metabolic health, increased by 29.8% to 99.3% depending on dose and duration
Peroxisome proliferator-activated receptor reduces endothelin-1-caused cardiomyocyte hypertrophy by inhibiting nuclear factor- B and adiponectin
Its FDA-approved and highly effective when combined with lifestyle changes
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