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Taken orally, its a combination of two medications bupropion and naltrexone which work together to curb cravings and reduce appetite, especially when emotional eating or overeating is present

These findings position GLP-1RAs as a potential fourth pillar of kidney-protective therapy in diabetes, alongside renin-angiotensin system inhibitors (RASi), SGLT2i, and finerenone, and suggest a shift toward rapid initiation of combination therapies for maximum kidney protection

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