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STEP 1 trial (Wilding et al., NEJM 2021) the one that sparked much of the global excitement around GLP-1s: The mean change in body weight from baseline to week 68 was 14.9 % in the semaglutide group as compared with 2.4 % with placebo Participants who received semaglutide had a greater improvement with respect to cardiometabolic risk factors and a greater increase in participant-reported physical functioning from baseline than those who received placebo. For the first time, a medication could achieve double-digit, sustained weight loss alongside meaningful improvements in health and daily function
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