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A Phase 2 study published in the New England Journal of Medicine in 2023 (Jastreboff et al.) reported substantial weight loss in participants with obesity

[49]conducted a double-blind, placebo-controlled, crossover trial in 42 healthy elderly Caucasian participants to assess the immunological effects and safety of an orally administered shiitake-derived -glucan (Lentinex)

We grouped the included trials into four subgroups based on the type of comparison to provide comparator-specific synthesis and subgroup analysis

Tamoxifen was also shown to have a similar effect on wound healing reducing inflammation and restoring wound healing time in the OVX mouse to that of the intact control and estrogen treated [184]

ACS Omega 8 , 2819628206 (2023)