semaglutide and suicide A recent post hoc analysis published in Obesity found tirzepatide vs. placebo was not associated with increased risk of depression symptoms. Rates of suicidal ideation behavior were low and similar to GLP-1 drugs and suicidal ideation:

The most advanced of them, danuglipron, has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space," said Mikael Dolsten, MD., PhD., chief scientific officer & president, Pfizer Research and Development

Al Ozairi E, Irshad M, Alkandari J, Sojan L, Alroudhan D, Alotaibi N, et al

Overall, several studies have shown that lifestyle modifications, including physical activity (particularly aerobic exercise), weight loss (including bariatric surgery), and treatment of CVD risk factors, may improve sexual function in men with ED [271,373,375-379]

However, the cost of generic semaglutide has not only decreased the cost of some brand-name versions

Significant weight gain may cause remaining fat cells to enlarge, affecting your results

How much weight can I lose with medical weight loss