Safety of semaglutide
This is likely to reflect the fact that oral dosing produces slower absorption and lower peak exposure, which might reduce recruitment of AP neurons that are sensitive to circulating factors
If diarrhea significantly impacts your quality of life or prevents you from taking your medication as prescribed, your provider may recommend dose adjustment, a temporary pause, or switching to a different formulation
See the Flow Wellness dose calculator to do this calculation
Additionally, the appetite-suppressing effects of these medications often lead to reduced food and fluid intake, which can further contribute to constipation if adequate fibre and fluids aren't maintained
Kuhre RE, Albrechtsen NW, Windelov JA, Svendsen B, Hartmann B, Holst JJ