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Inclusion criteria involved pre-clinical and clinical studies investigating the effects of GLP-1 agonists dulaglutide, liraglutide, semaglutide or exenatide on A and tau pathology

These are safe, inexpensive options to trial during your first 4 weeks, though they work best alongside dietary and lifestyle modifications

The first 48 hours favor cold (to limit initial inflammation), and the period after 48 hours favors warmth (to promote resolution)

The steering committee integrated the literature evidence and wrote the graded recommendations and the underlying rationale, graded the strength of the recommendations and developed practice points

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Among these, dysglycemia is an important predisposing factor: studies have shown that chronic inhibition of cerebral energy metabolism, especially reduced glucose utilization, can induce epileptic seizures (17), while decreasing glycogenolysis and increasing glucose utilization and metabolism via the TCA cycle exerts an antiseizure effect (19)