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GLP-1RA-treated mice showed an enhanced response to insulin, as reflected by a more pronounced decline in blood glucose during the first 60 min post-injection compared to untreated db/db mice (Fig

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However, the contributions of the peripheral nervous system and the CNS in the mediation of the anorexic effects of the GLP-1RAs is still not completely understood [23]

Dose reduction or temporary discontinuation may be necessary

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Murthy SN, Hilaire RC, Casey DB, Badejo AM, McGee J, McNamara DB, Kadowitz PJ, Fonseca VA: The synthetic GLP-I receptor agonist, exenatide, reduces intimal hyperplasia in insulin resistant rats