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The methodological limitations identified by AMSTAR 2 indicate that some pooled effect-size estimates may be vulnerable to selection and reporting bias

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This drop closely correlates with the well-known reduction in regenerative capacity seen across multiple organ systems as we age

Unlike larger synthetic copper peptides, GHK-Cu occurs naturally in human plasma, urine, and saliva, which makes it a primary reference compound for studying endogenous copper-mediated regeneration pathways

Available at: 119 MaedaD.AkiyamaY.MorikawaT.KunitaA.OtaY.KatohH.et al (2015)