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acnes lives in skin follicles and pores and is linked to acne
coli K-12 strain was selected as a Gram-negative control due to its well-characterized lipopolysaccharide (LPS)-induced inflammatory properties and regulatory role in EMs pathogenesis [27, 44]
Tolerability screening The lower systemic exposure from nasal delivery could serve as a tolerability screen before full-dose subcutaneous injection
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Notably, one participant with a history of B12-responsive acne developed lesions following B12 administration during the study
