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Lastly, they propose that tirzepatide causes a thermogenic-like amino acid profile in BAT, which could explain why obese IR mice have lower systemic BCAA levels [82]
According to Rubino, clinical trials are now being planned to assess whether higher doses of GLP-1 drugs can be used in the acute phase to help patients lose weight, followed by lower "maintenance" doses, which come with fewer side effects and can be prescribed on a long-term basis
Most participants (78%) were women, with an average age of 52.7
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