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8 The mechanisms of APAP-induced cell death, which apply to both animals and humans, include the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 2E1 (Cyp2E1), depletion of hepatic GSH, and protein adduct formation, primarily in mitochondria

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Food Chem Toxicol 46:10791088 Acknowledgements The authors would like to thank Professor Zubeyde BAYSAL (Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir/Turkey) for generously providing laboratory facilities and some needed reactants

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Despite these limitations, a growing body of recent research (Dong et al., 2024

Two people using identical protocols may have completely different results simply because one received genuine product while the other received degraded, contaminated, or counterfeit material