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These considerations exemplify a broader theme for NGPs: achieving their therapeutic potential will require integrating high-resolution hostmicrobiome science with appropriate regulatory frameworks, advanced manufacturing technologies, and precision medicine approaches that align specific NGPs or consortia with defined clinical indications and patient subgroups

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All analytes were separated on an ACQUITYUPLC BEH Amide column (2.1 mm 100 mm, 130 , 1.7 m, Waters Corporation, Milford, Massachusetts) with an upstream Van Guard UPLC BEH Amide pre-column (2.1 mm 5 mm, 1.7 m, Waters Co., Milford, MA) using water and acetonitrile/water as mobile phases

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Further examination of the effect of incubation media is warranted

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