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PWA mice were placed on their cage grid, and pictures of the interscapular brown adipose tissue area were taken 6 h after acute administration with GLP1/E, GLP1/GIP, or GLP1/GIP/Glucagon (10 nmol/kg)

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After 68 weeks, participants receiving a 2.4 mg weekly semaglutide dose experienced a 49% reduction in C-reactive protein (CRP), while those on a 1 mg weekly dose saw a 42% reduction compared to placebo

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Guided by this structural information, we design peptide agonists with potent in vivo activity in a mouse model of diabetes