2024, Sep;379:114887
The nausea is worse than it should be
The industry landscape has changed dramatically, with Pfizer's two core GLP-1R small molecule agonists, Danuglipron and Lotiglipron, both failing, while Structure Therapeutics' stock experienced a rollercoaster-like fluctuation, instilling a sense of panic among investors
However, the complete datasets were never fully published, which makes independent evaluation difficult
Afr J Biotechnol 10:634863 Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A (2003) Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK
The panel cited the high rate of acute kidney injury (AKI) in patients assigned to the treatment group, which it said could potentially be attributed to ITCA 650