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In the past 10 years, anti-TNFs indications have expanded to include non-radiographic axial spondyloarthritis (AxSpA), paediatric enthesitis-related arthritis, paediatric ulcerative colitis (UC), hidradenitis suppurativa (including adolescents) and non-infectious uveitis (including children) (Table 1)

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Differential effects between marimastat, a TNF- converting enzyme inhibitor, and anti-TNF- antibody on murine models for sepsis and arthritis

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Rather than cannibalizing significant market share from injectables, oral formulations are more likely to expand the total patient population eligible for these therapies