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The serine deprivation-dependent induction is regulated by the activating transcription factor 4 (ATF4) and can be reversed by the addition of glycine and serine, but not by other amino acids like leucine or cysteine (Hamano et al., 2020)

Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling

Yorimitsu, T., Nair, U., Yang, Z

doi: 10.1007/s00296-010-1606-z 76 LittleCBBaraiABurkhardtDSmithSMFosangAJWerbZet al