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[1] [8] The combined stimulation of these three pathways is intended to create a synergistic effect on appetite suppression, caloric intake reduction, and metabolic rate

It can be triggered by rapid weight loss, reduced calorie intake, or changes in protein and micronutrient intake , and usually resolves once weight and nutrition stabilise

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These data indicate that the uptake mechanism of nanocarriers was mediated by endocytosis

J Am Soc Nephrol 13:708714