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Treatment Timeline During the first two weeks, some patients notice immediate improvement in mobility due to reduced inflammation, while others experience gradual changes
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What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work
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What the SURMOUNT-5 head-to-head actually proved
