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369 In the phase 1b trial of AMG-232 monotherapy or trametinib in patients with R/R AML, 370 1 patient had DLT, 31% (4/13) of patients expressing wild-type p53 had a response, and no patients expressing mutant p53 had a response
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Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M , Croce CM
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