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(PubMed)

SGLT2is was associated with significant improvements in homeostatic model assessment for insulin resistance (HOMA-IR) and fasting plasma glucose, and in combination with metformin, SGLT2is significantly improved triglycerides

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The treatment is administered to reduce the risk of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes who were confirmed with cardiovascular disease

Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11