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Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness
In a series of EPR experiments, Miller et al
As such, GLP-1 receptor agonist medications mimic GLP-1 but are structurally modified to resist degradation by the enzyme that breaks down the natural hormone
e-f , ALT and AST liver damage serum markers (n = 6 for Control, n = 9 for GGsTop) (e) and percent change in body weight (n = 10 per group) (f) in mice treated bi-daily with vehicle (saline) or 5 mg/kg i.p
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