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First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)
The most commonly reported effects are gastrointestinal nausea, cramping, or loose stools at the higher end of oral dosing, and a distinctive fishy body or breath odor caused by trimethylamine, a metabolite of carnitine
This brings about excruciating abdominal pain, vomiting, and nausea
Effects of GLP-1 analogs on appetite, energy intake, and body fat distribution
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