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A study employing network pharmacology to analyze gypenoside (GP), a main bioactive compound derived from the traditional Chinese herb Gynostemma, highlighted its potential to reduce the effects of crystalline pathomorphological changes of DC by regulating the P53/SLC7A11/GPX4 pathway (142)
In human bronchial epithelial cells exposed to CSE, both Caspase-3 activation (apoptosis marker) and GPX4 downregulation, along with elevated lipid ROS (ferroptosis marker), can be observed, indicating that under high oxidative stress, the two forms of PCD can occur in parallel or even transform into each other (206)
Gastroenterology 154 , 20682086 (2018)
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