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Patients were considered as receiving the study drug class for the period during which prescriptions for the same drug class were refilled before the estimated end date of the most recent prescription, including a grace period of 90 days to account for irregular drug use

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If using injectable semaglutide, schedule B12 injections on different days to prevent injection fatigue

The primary driver is the need to manage dose escalation and refill tasks after GLP-1 treatment starts

Lalau et al., 2021)

While they offer lower pricing for non-GLP-1 oral medication regimens, their semaglutide paths are financially prohibitive for most self-paying patients who do not have comprehensive insurance coverage