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This architecture creates an extraordinarily high binding affinity (pK = 16.44), roughly 10 million times stronger than other tripeptides and comparable to albumins copper binding
In laboratory settings, the peptide has been studied in preclinical models that examine cellular signaling and experimental responses across multiple tissue systems
MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma
Based on the favorable outcomes of these studies like excellent anti-tumor efficacy due to higher intratumoral concentration of docetaxel with improved safety index, the Phase I clinical trial having 52 individuals suffering from advanced tumors (ClinicalTrials.gov Identifier: NCT01300533), exhibited well toleration with negative toxicity index and a recommendation of 60 mg/m 2 dose for ongoing phase 2 trials on 42 patients having metastatic CRPC (ClinicalTrials.gov Identifier: NCT01812746) [253, 254]
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