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For the vast majority of people taking B12 at standard supplemental doses, this isn't a concern

[1] [3] The medication works by activating both GIP and GLP-1 receptors, enhancing glucose-dependent insulin secretion, suppressing inappropriately elevated glucagon secretion, and slowing gastric emptying

No human studies have assessed chronic administration effects on brain structure, function, or neurotransmitter systems

Safety reports often rely on observational studies or individual case reports , which cannot prove causality

Resting heart rate decreases