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Moreover, enhanced microglial activation was also observed in various PD animal models, including -synuclein overexpression models, as well as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA) and rotenone neurotoxin-induced mice, rats and monkeys (Roca et al., 2011)
PubMed Krivic, A., Anic, T., Seiwerth, S., Huljev, D., Sikiric, P
Relevant for clinical practice, our findings show that treatment with semaglutide lowered the risk of MACE compared to sitagliptin, while tirzepatide showed at least comparable benefit to dulaglutide, an older GLP-1 receptor agonist with established cardiovascular efficacy
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