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Tirzepatide trials report similar tolerability, with 4-8% discontinuation due to adverse events, predominantly gastrointestinal

It also binds hormone receptors, including ER, to inhibit hormone-induced apoptosis

This makes it a valuable tool for athletes, bodybuilders, and those looking to combat growth hormone deficiency

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Though the regulatory agency generally does accept the determinations of panels like these, it can and has rejected panel votes in the past