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In addition to having anti-inflammatory properties, EETs may have numerous benefits such as antioxidant effects, a reduction in mitochondrial dysfunction and apoptosis and improved cerebral blood flow (Pallas et al., 2020)

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This reality supports the chronic disease model where ongoing therapy, rather than a finite course, produces optimal long-term outcomes

In the only direct evaluation of brain insulin resistance in PD, insulin signaling abnormalities were identified in the dorsolateral prefrontal and posterior parietal cortex of those with cognitive impairment, but not in those who were cognitively normal [72]